Endocrine Abstracts

Introduction: Prostate cancer (PC) is dependent on androgen receptor (AR) activation by its canonical ligands testosterone and 5α-dihydrotestosterone (DHT). Intratumoural androgens persisting after castration give rise to castration-resistant PC (CRPC). These intraprostatic androgen levels are hypothesized to result from either adrenal androgen conversion or intratumoural de novo DHT synthesis through the classic or alternative pathways. Quantifying the steroid f...

Background: A metastatic mesenteric mass is a hallmark of small intestinal neuroendocrine tumours (SI-NETs). However, little is known about the evolution of a SI-NET-associated mesenteric mass over time.Methods: Retrospectively, 530 patients with proven SI-NET and ≥2 available CT-scans were assessed for clinical characteristics at diagnosis and the presence and growth of a mesenteric mass on every consecutive CT-scan until end of follow-up or resec...

Objective: A mesenteric mass with surrounding mesenteric fibrosis (MF) is a hallmark of small intestinal neuroendocrine tumours (SI-NETs) and known to induce abdominal complications. However, little is known on the evolution over time and the pathways involved in progression. Our aim was to assess the development of the metastatic mesenteric mass over time and find predictors for progression.Methods: Retrospectively, 530 patients with proven SI-NET and &...